This mixed-method research sought to identify the factors, challenges and strategies that enable and strengthen collaborative research practice in academia. Participants of the study are purposively chosen, self-selected faculty and students from an external campus and a unit in the main campus of a state university in Bulacan, Philippines, who have successfully completed collaborative research writing projects, presented collaborative research projects in conferences and symposia, or published said collaborative research projects. Data were gathered using a researcher developed instrument, validated, and checked for reliability. Analysis of results using principal components analysis led to the development of the DRREAM (Diversity, Role assignment, Relationship-building and peer interdependence, Ergonomic, flexible and adaptable processes, Acquisition of knowledge, skills and expertise, Motivation consideration) model, a conceptual framework on factors that strengthen effectual collaborative research writing; while the use of thematic analysis enabled the formulation of IPP (Individual, Professional and Personal) model, a conceptual framework on strategies to overcome challenges faced by collaborators in a collaboration research project. Finally, an Action Plan Framework for Effectual Collaborative Research Writing is proposed to promote the culture of collaborative research practices among the members of the academia.