COMPUTER-ASSISTED CLASSES ON MEDICINAL CHEMISTRY OF BARBITURATES AND THIOBARBITURATES
Title | COMPUTER-ASSISTED CLASSES ON MEDICINAL CHEMISTRY OF BARBITURATES AND THIOBARBITURATES |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Kaczor, AA |
Journal | Problems of Education in the 21st Century |
Volume | 28 |
Start Page | 61-71 |
Date Published | April/2011 |
Type of Article | Original article |
ISSN | 1822-7864 |
Other Numbers | ICID: 939899 |
Keywords | computer-assisted classes, ICT, improving classroom teaching |
Abstract | The purpose of this study is elaboration of computer classes for pharmacy or chemistry students on ADMET parameters of barbiturates and thiobarbiturates in the context of their molecular structure and gathering students’ feedback on the classes. Barbiturates and thiobarbiturates are derivatives of barbituric acid and thiobarbituric acid, respectively. These drugs, depending on clear differences in their structure, exert a variety of effects on the central nervous system, ranging from mild sedation to total anesthesia. Barbiturates may be used as hypnotics, anxiolytics and anticonvulsants whereas thiobarbiturates can be applied for the induction of general anesthesia. At present barbiturates are usually replaced by benzodiazepines which are less dangerous at overdose. Nevertheless, they remain a model group of drugs to discuss structure-activity relationship, in particular the effect of lipophilicity on the activity profile. |
URL | http://journals.indexcopernicus.com/abstract.php?icid=939899 |
Refereed Designation | Refereed |
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